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Severity of presentation depends on: Percentage of MetHb Rate of increase in MetHb levels The intrinsic ability of the patient to prevent or reduce MetHb The patients underlying functional status Symptoms depend on the level of MHb and its rapidity of formation, and include: 12 Dyspnea Anxiety Headache Fatigue Weakness CNS depression Dizziness Cyanosis Seizures Signs include: Cyanosis: As little as 1.5 g methemoglobin in 100 ml blood (1.5 g%) can produce clinically recognizable cyanosis

Naunyn Schmiedebergs Arch Pharmacol 393, 23552364.Google ScholarPubMed in vitro leads to impaired energy generation and enhanced oxidative stress

Cell Mol Life Sci 74 , 31853204, (2017)